Thermo Fisher Scientific KCNQ1 Polyclonal Antibody
Human KCNQ1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 0.05 mg/mL 농도. 심장 및 청각 관련 KCNQ 채널 연구용으로 권장.
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Thermo Fisher Scientific KCNQ1 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KCNQ1 (Product #RP-89645) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791067 |
Product Specific Information
Immunogen sequence:
PRSHTLLSPS PKPKKSVVVK KKKFKLDKDN GVTPGEKMLT VPHITCDPPE ERRLDHFSVD GYDSSVRKSP TLLEVSMPHF MRTNSFAEDL DLEGETLLTP ITHISQLREH HRATIKVIRR
Target Information
Voltage-gated K⁺ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells.
KCNQ1, together with KCNE1, forms a channel predominantly expressed in the heart and cochlea, regulating slow depolarization-activated potassium currents.
Mutations in KCNQ1 and KCNE1 are linked to cardiac diseases, and KCNQ4 mutations are implicated in deafness.
KCNQ proteins typically have six transmembrane domains and function as tetramers.
KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in tissues including the cochlea, particularly in outer hair cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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