Thermo Fisher Scientific LPIN1 Monoclonal Antibody (OTI7F5)
LPIN1 단백질을 표적하는 Mouse IgG2a 단일클론 항체로 Western blot 및 IHC(Paraffin)에 적합. 높은 특이성과 재현성을 제공하며, 인간 시료 반응성 검증 완료. 액상 형태로 안정적이며 장기 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7F5 |
| Immunogen | Full length human recombinant protein of LPIN1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723329 |
Target Information
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2, and Lipin-3. All contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain, and a carboxy-terminal (CLIP) domain.
LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. It selectively activates PGC-1A target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation, by inducing expression of the nuclear receptor PPARA.
LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. Abundance of LPIN1 promotes fat accumulation and insulin sensitivity, while deficiency may lead to insulin resistance and lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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