Thermo Fisher Scientific HtrA2/Omi Polyclonal Antibody
HtrA2/Omi 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트에 반응합니다. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공됩니다. 연구용 전용 시약입니다.
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Thermo Fisher Scientific HtrA2/Omi Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human HtrA2, amino acids 355–458 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif essential for anti-apoptotic activity. A serine protease named Omi/HtrA2 is released from mitochondria upon apoptotic induction and binds to IAP. Similar to Smac/DIABLO, mature Omi contains a conserved IAP-binding motif (AVPS) at its N terminus. Deregulated cytoplasmic expression of Omi induces apoptosis, suggesting its participation in the mitochondrial apoptotic pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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