Thermo Fisher Scientific HEY1 Polyclonal Antibody
HEY1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 사용 가능. 인간 및 다중 종 반응성. 액상 형태로 0.5 mg/mL 농도, PBS/sucrose buffer에 보존. Notch 신호전달 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 3 publications |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–8 µg/mL | View publications |
| Immunocytochemistry (ICC/IF) | – | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human HEY1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2576326 |
Product Specific Information
- Peptide sequence: PQNGHGNAGT TASPTEPHHQ GRLGSAHPEA PALRAPPSGS FGPVLPVVTS
- Sequence homology:
Cow: 79%
Dog: 86%
Guinea Pig: 93%
Horse: 93%
Human: 100%
Mouse: 93%
Rabbit: 79%
Rat: 93%
Target Information
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain.
HEY1 acts as a downstream effector of Notch signaling and may be required for cardiovascular development. It functions as a transcriptional repressor binding preferentially to the canonical E-box sequence (5'-CACGTG-3'), repressing transcription by cardiac transcriptional activators GATA4 and GATA6.
HEY1 is also expressed during nervous system development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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