Thermo Fisher Scientific IFIT3 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: A431, HeLa, Molt-4, Raji
• Predicted reactivity: Pig (80%), Chimpanzee (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

IFN-induced antiviral protein which acts as an inhibitor of cellular and viral processes including cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by bridging TBK1 to MAVS, leading to TBK1 activation and IRF3 phosphorylation. Phosphorylated IRF3 translocates into the nucleus to promote antiviral gene transcription. Exhibits antiproliferative activity via upregulation of CDKN1A/p21 and CDKN1B/p27. IFIT3 sequesters COPS5 in the cytoplasm, increasing nuclear CDKN1B/p27 levels, and downregulates MYC to enhance CDKN1A/p21 expression. Can negatively regulate the apoptotic effects of IFIT2.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.