Thermo Fisher Scientific IFIT3 Polyclonal Antibody
Human IFIT3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태입니다. A431, HeLa 등에서 양성 대조로 사용 가능하며, 연구용으로만 제공됩니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–273 of Human IFIT3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2547012 |
Product Specific Information
- Recommended positive controls: A431, HeLa, Molt-4, Raji
- Predicted reactivity: Pig (80%), Chimpanzee (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
IFN-induced antiviral protein which acts as an inhibitor of cellular and viral processes including cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by bridging TBK1 to MAVS, leading to TBK1 activation and IRF3 phosphorylation. Phosphorylated IRF3 translocates into the nucleus to promote antiviral gene transcription. Exhibits antiproliferative activity via upregulation of CDKN1A/p21 and CDKN1B/p27. IFIT3 sequesters COPS5 in the cytoplasm, increasing nuclear CDKN1B/p27 levels, and downregulates MYC to enhance CDKN1A/p21 expression. Can negatively regulate the apoptotic effects of IFIT2.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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