Thermo Fisher Scientific MAVS Polyclonal Antibody
MAVS 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, ELISA, Immunoprecipitation에 적합. 합성 펩타이드 면역원 사용. 고순도 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 500–540 of human mitochondrial antiviral-signaling protein isoform 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA.
MAVS is a mitochondrial membrane protein critical in IFN-beta signaling, recruiting IRF-3 to RIG-I and activating NF-kappa-B. It interacts with innate immune components such as TRIF, TRAF2, and TRAF6, and with kinases IKK-alpha, IKK-beta, and IKK-iota.
Cleavage of MAVS by Hepatitis C virus (HCV) protease enables viral immune evasion. Multiple isoforms of MAVS are known to exist.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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