Thermo Fisher Scientific D4S234E Polyclonal Antibody, FITC
D4S234E(NEEP21) 단백질을 인식하는 FITC 결합 폴리클로날 항체입니다. Western blot, IHC, ELISA, IP 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 신경세포 단백질 연구용으로 적합하며, 형광 검출에 최적화된 제품입니다.
- 카탈로그번호
- NSG1-FITC
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 140–190 on human Neuron-specific protein family member 1 |
| Conjugate | FITC (Fluorescein isothiocyanate) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NEEP21 (Neuron-enriched endosomal 21kDa protein), also known as brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21, or D4S234E, is a single-pass type II membrane protein belonging to the NSG family.
It is highly expressed during neuronal maturation but is downregulated in adult tissues. NEEP21 predominantly localizes to Rab4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons.
NEEP21 associates with GRIP1 and GluR-2, mediating the surface expression of GluR-2. When this interaction is disrupted, GluR-2 accumulates in early endosomes, leading to changes in synaptic current properties.
Additionally, NEEP21 forms a complex with the SNARE protein Syntaxin 13 (Syntaxin 12) and participates in the recycling of transferrin receptors (TFRs) and NTR2 (Neurotensin receptor 2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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