Thermo Fisher Scientific PTCH Monoclonal Antibody (OTI5C7)
PTCH 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI5C7). Western blot, IHC, ICC/IF에 적합. Human 시료 반응성. Affinity Chromatography로 정제된 액상 항체로, 1 mg/mL 농도. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 122–436 of PTCH1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725144 |
Target Information
The PTCH1 gene encodes a member of the patched gene family. The encoded protein acts as the receptor for sonic hedgehog, a secreted molecule involved in embryonic structure formation and tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of PTCH1 have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, and holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms; some additional splice variants have been described but their full-length sequences and biological validity remain uncertain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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