Thermo Fisher Scientific FREM2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human FREM2. Recombinant protein control fragment (Product #RP-90330). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FREM2,uniProtId:Q5SZK8-1,ncbiNodeId:9606,antigenRange:2326-2451,antigenLength:3169,antigenImageFileName:PA5-55986_FREM2_Q5SZK8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55986_FREM2_Q5SZK8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641731

Product Specific Information

Immunogen sequence: TFDGVREMRE AFTVHLKPDE NMIAEMQLTK AIVYIEEMSS MADVTFPSVP QIVSLLMYDD TSKAKESAEP MSGYPVICIT ACNPKYSDYD KTGSICASEN INDTLTRYRW LISAPAGPDG VTSPMR

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 84%.

Target Information

FREM2 is a member of the FRAS1-related extracellular matrix protein family and like FREM1, mutations in the FREM2 gene are associated with Fraser syndrome. FREM2 localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes and is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The FREM2 gene is one of several genes whose transcription is affecteded by TFAP2C, a transcription factor involved in mammary development, differentiation, and oncogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.