Thermo Fisher Scientific DMTF1 Polyclonal Antibody
DMTF1 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western blot에 최적화되어 있으며, 고순도 액상 형태로 제공됩니다. 암 억제 관련 연구 및 단백질 발현 분석에 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-DAHVSKFSDQNSTE, from the internal region of DMTF1 (aa629–642) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2554524 |
Product Specific Information
- Predicted to react with dog, pig, and cow based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
The DMTF1 gene encodes a transcription factor with a cyclin D-binding domain, three central Myb-like repeats, and acidic transactivation domains at both termini.
It is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF, thereby influencing the ARF-p53 pathway to arrest cell growth or induce apoptosis.
Additionally, it activates transcription of aminopeptidase N and may contribute to hematopoietic cell differentiation.
Its transcriptional activity is regulated by binding of D-cyclins.
This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancers and is considered a potential prognostic and gene-therapy target.
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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