Thermo Fisher Scientific CD9 (TSPAN29) (Motility-Related Protein-1) Monoclonal Antibody (CD9, 1619)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophils, stimulated T lymphocytes, and by neurons and glial cells in the peripheral nervous system.
CD9 belongs to the tetraspanin family, which traverses the membrane four times. In pre-B cells and platelets, CD9 regulates cell activation and aggregation, possibly through association with integrin CD41/CD61 (GPIIb/GPIIIa).
It is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion. CD9 plays roles in cell attachment, proliferation, and is necessary for the association of heterologous MHC II molecules on dendritic cells, which is important for effective T-cell stimulation.
CD9 functions in differentiation, adhesion, and signal transduction, and its expression plays a critical role in suppressing cancer cell motility and metastasis. CD9 is also considered a metastasis suppressor in solid tumors.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.