Thermo Fisher Scientific BRCC36 Polyclonal Antibody
BRCC36 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. IHC 및 IHC(P) 실험에 적합하며, 인간을 비롯한 다양한 종에서 반응 예측. 액상 형태, 0.25 mg/mL 농도, 항원 친화 크로마토그래피 정제. 연구용 전용 제품.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 266 and 316 of human BRCA1/BRCA2-containing complex subunit 36 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse, Horse, Pig, Panda, Orangutan, Monkey, Northern white-cheeked gibbon, Greater horseshoe bat, and Little brown bat
Target Information
BRCC36 forms a holoenzyme complex with BRCA1, BRCA2, RAD51, and BRCC45, possessing ubiquitin E3 ligase activity. Aberrant BRCC36 levels are detected in sporadic breast tumors. Depletion of BRCC36 or BRCC45 increases sensitivity to ionizing radiation and causes G2/M checkpoint defects, indicating its role in cellular survival after DNA damage. BRCC36 is essential for BRCA1 phosphorylation and nuclear foci formation following radiation, suggesting its potential as a target for radiation-resistant breast cancer treatment. At least two isoforms of BRCC36 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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