Thermo Fisher Scientific RNASEH2A Polyclonal Antibody
Thermo Fisher Scientific의 RNASEH2A Polyclonal Antibody는 인간 RNASEH2A 단백질을 인식하는 토끼 유래 IgG 항체입니다. WB, IHC, ICC/IF에 사용 가능하며, 높은 특이성과 재현성을 제공합니다. 항원 친화 크로마토그래피로 정제되어 연구용으로 적합합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50–1:400 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Ribonuclease H2 Subunit A (amino acids 1–299 of target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2903897 |
Target Information
Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. Their major role is to remove the RNA strand from RNA/DNA hybrids formed during DNA replication and repair. RNAse H2 consists of three subunits, all required for RNAse activity. Mutations in RNAse H2A or other subunits are linked to Aicardi-Goutieres syndrome (AGS), a neurological disorder with symptoms similar to viral brain infections, including elevated IFN-alpha levels in cerebrospinal fluid. Similar conditions occur with TREX1 mutations, suggesting that RNAse H2 and TREX1 share functional roles in preventing accumulation of intracellular nucleic acids that trigger inflammatory responses via innate immune activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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