Thermo Fisher Scientific IRAK1BP1 Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 Thermo Fisher Scientific의 IRAK1BP1 폴리클로날 항체로, IHC(P) 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체이며, 액상 형태로 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific IRAK1BP1 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human IRAK1BP1 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 0.1M Glycine, 10% Glycerol |
| Contains | 0.01% Thimerosal |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at −20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2735962 |
Product Specific Information
- Positive Control: Target recombinant protein
- Predicted Reactivity: Rhesus Monkey (97%), Bovine (88%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. It contains an intrinsically disordered region that associates with HSPA1 and HSPA8, interacts directly with IRAK1, and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway, where TNF-alpha induces NF-kappa-B gene transcription leading to inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits TNFRSF1A-induced NF-kappaB activity. Localized to the nucleus and cytoplasm, SIMPL requires phosphorylation of Ser-56 and/or Ser-62 for full activation.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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