Thermo Fisher Scientific IRAK1BP1 Polyclonal Antibody

Thermo Fisher Scientific IRAK1BP1 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Positive Control: Target recombinant protein
• Predicted Reactivity: Rhesus Monkey (97%), Bovine (88%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. It contains an intrinsically disordered region that associates with HSPA1 and HSPA8, interacts directly with IRAK1, and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway, where TNF-alpha induces NF-kappa-B gene transcription leading to inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits TNFRSF1A-induced NF-kappaB activity. Localized to the nucleus and cytoplasm, SIMPL requires phosphorylation of Ser-56 and/or Ser-62 for full activation.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.