Thermo Fisher Scientific CD46 Recombinant Rabbit Monoclonal Antibody (7D12)
CD46 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 IHC(P) 등에 사용 가능. 인간 시료 반응성. HEK293 세포에서 발현, Affinity chromatography로 정제. PBS/glycerol buffer에 보관, 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7D12 |
| Immunogen | A synthesized peptide derived from human CD46 (target family: CD46, UniProt ID: P15529-1, antigen range: 50–65, antigen length: 392) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.43 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C or −80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898300 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments. It regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alters T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 protects placental tissue and is expressed on the inner acrosomal membrane of spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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