Thermo Fisher Scientific SPIB Polyclonal Antibody
Rabbit polyclonal antibody targeting Spi-B transcription factor. Suitable for Western blot applications at 1–2 µg/mL. Recognizes synthetic peptide of Spi-B protein. Supplied as a liquid, 0.5 mg/mL concentration, stored at 4°C short term or -20°C long t...
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Applications
- Western Blot (WB): 1.0–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (135 PLDSPALEVSDSESDEAL 152) of Spi-B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2540795 |
Target Information
Spi-B is a transcription factor belonging to the ETS family with a conserved ETS domain that mediates specific DNA binding. It can form homotypic interactions and interacts with IRF4, CREBBP, EP300, SPI1/PU.1, JUN, and TBP. As a sequence-specific transcriptional activator, it binds to the PU-box (5'-GAGGAA-3'), acting as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. It is mainly expressed in plasmacytoid dendritic cells (pDCs) and promotes their development and antiviral responses. Spi-B is not expressed in T-cells or granulocytes but may be present in liver stem cells and B-cells, contributing to B-cell receptor signaling and normal B-cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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