Thermo Fisher Scientific CD357/GITR Monoclonal Antibody (GITR/1585)
인간 GITR(TNFRSF18) 단백질을 인식하는 Mouse IgG3 단클론 항체로 ELISA 등 면역분석에 적합. Protein A/G로 정제된 액상 형태, 보존제 무첨가. -20°C에서 보관하며 반복 동결·해동은 피해야 함.
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Applications
- ELISA (Assay-dependent)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GITR/1585 |
| Immunogen | Human full-length TNFRSF18 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a protein encoded by the TNFRSF18 gene located on chromosome 1p36.33. This receptor is part of the TNF-receptor superfamily and shows increased expression upon T-cell activation. It plays a key role in maintaining immunological self-tolerance mediated by CD25(+)CD4(+) regulatory T cells. Mouse knockout studies indicate its involvement in CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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