Thermo Fisher Scientific NOTCH4 Polyclonal Antibody
NOTCH4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot과 IHC(P)에서 사용 가능. Human, Mouse, Rat에 반응하며, 액상 형태로 제공. Affinity chromatography로 정제되어 높은 특이성과 재현성을 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NOTCH4 (Accession Q99466), corresponding to amino acid residues R1474–G1524 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900299 |
Product Specific Information
Antibody detects endogenous levels of total NOTCH4.
Target Information
The NOTCH4 gene encodes a Type I transmembrane protein, a member of the Notch family. These proteins share structural features such as multiple EGF-like repeats in the extracellular domain and diverse domains in the intracellular region. Notch proteins regulate developmental processes by controlling cell fate decisions. NOTCH4 is cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. It functions as a receptor for membrane-bound ligands and may play roles in vascular, renal, and hepatic development. Additionally, it has been associated with susceptibility to schizophrenia in some cases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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