Thermo Fisher Scientific Involucrin Monoclonal Antibody (SY8)

Applications

Tested Dilution

Publications

Western Blot (WB)

0.75 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

-

Immunoprecipitation (IP)

Assay-dependent

-

Product Specifications

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

SY8

Immunogen

Pure involucrin from human keratinocytes. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Involucrin,uniProtId:P07476-1,ncbiNodeId:9606,antigenRange:1-585,antigenLength:585,antigenImageFileName:MA1-90573_Involucrin_P07476-1_House_mouse.svg,antigenImageFileNamePDP:MA1-90573_Involucrin_P07476-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2249265

Product Specific Information

MA1-90573 detects Involucrin from non-human primate, porcine, and human samples.

Target Information

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.