Thermo Fisher Scientific PDE6G Monoclonal Antibody (OTI2F5), TrueMAB
PDE6G 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(파라핀 절편)에 적합합니다. Human 시료에 반응하며, Affinity chromatography로 정제된 액상 형태입니다. 시그널 전달 연구 및 PDE6 관련 단백질 분석에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F5 |
| Immunogen | Full length human recombinant protein of human PDE6G produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.72 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The second messengers cAMP and cGMP are key regulatory molecules involved in various signal transduction pathways. Their levels are controlled by synthesis via nucleotide cyclases and hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that convert 3',5'-cyclic nucleotides to nucleoside 5'-monophosphates.
PDE6 functions as the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. It consists of several subunits: rod and cone-specific catalytic subunits (alpha', alpha, beta), the inhibitory subunit gamma, and subunit delta of unknown function. The catalytic core is formed by alpha'/alpha' homodimers in cones and alpha/beta heterodimers in rods. The C-terminus of both catalytic and inhibitory subunits undergoes methylation, myristoylation, and prenylation, which are essential for complex assembly and membrane association.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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