Thermo Fisher Scientific SLC39A2 Polyclonal Antibody

Thermo Fisher Scientific SLC39A2 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: EIESQIQKFM VQNRSASERN SSGDADSAHM EYPYGELIIS LGFFFVFFLE
• Sequence homology: Human: 100%

Target Information

The zinc transporter ZIP2, also known as SLC39A2, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP3, ZIP2- mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are downregulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)