Thermo Fisher Scientific AXL Polyclonal Antibody
AXL 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 Protein A 정제, 안정적인 액상 형태로 연구용 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human AXL, amino acids 151–250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
AXL is a chronic myelogenous leukemia-associated oncogene also linked to colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors such as GAS6. It plays a role in cell proliferation and apoptotic cell clearance through TAM receptor pathways. Deficiency in TAM receptors can lead to autoimmune phenotypes similar to systemic lupus erythematosus. AXL may also function as an entry receptor for filoviruses and identifies a subpopulation of human dendritic cells (Siglec 6+/Axl+). Its expression can be upregulated by TLR ligands, and soluble AXL levels may indicate inflammation or cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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