Thermo Fisher Scientific MLK4 Polyclonal Antibody
MLK4 단백질을 검출하기 위한 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합. 인간 시료에 반응하며, Affinity chromatography로 정제된 액상 형태. -20°C 보관, 1 mg/mL 농도.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP3K21 (Accession Q5TCX8), corresponding to amino acid residues S862–A912 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818209 |
Product Specific Information
Antibody detects endogenous levels of total MLK4.
Target Information
MLK4 (Mixed Lineage Kinase 4) belongs to the MAP kinase kinase kinase (MAP3K) superfamily, containing both serine/threonine and tyrosine kinase activities in its catalytic domains. The kinase structure includes an N-terminal Src homology (SH3) domain, a kinase domain, a leucine zipper region, and a CDC42/RAC-interactive binding (CRIB) motif, with divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas and functions as a negative regulator of TLR4. It does not activate JNK1/MAPK8, p38/MAPK14, or ERK2/MAPK1 pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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