Thermo Fisher Scientific ZFP36 Polyclonal Antibody
인간 ZFP36 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 적용 가능. 합성 펩타이드 면역원 사용, Affinity Chromatography로 정제됨. PBS 및 2% sucrose 저장 완충액, -20°C 보관. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human ZFP36 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609098 |
Product Specific Information
Peptide sequence:
PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE
Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Human: 100%
Mouse: 93%
Rabbit: 100%
Rat: 93%
Sheep: 100%
Target Information
ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes, supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by other members of the MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may contribute to higher rheumatoid arthritis disease activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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