Thermo Fisher Scientific ALDH3A1 Monoclonal Antibody (OTI1B6)
인간 ALDH3A1 단백질을 인식하는 Mouse IgG2a 단클론 항체. WB, IHC, ICC/IF, Flow Cytometry에 사용 가능. 고순도 Affinity Chromatography로 정제된 액상 형태이며, 안정적 저장을 위한 PBS/BSA/glycerol buffer 포함. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B6 |
| Immunogen | Full length human recombinant protein of ALDH3A1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2722838 |
Target Information
Aldh3A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldh3A1 is highly expressed in the stomach and even more strongly in the cornea, representing between 5 to 50% of the water-soluble protein fraction in mammalian corneas. It is thought that Aldh3A1 acts to protect the cornea from UV-induced oxidative stress by detoxifying reactive aldehydes and through direct absorption of UV energy. However, corneas from Aldh3A1- mice are indistinguishable from those from wild-type mice; mice lacking both Aldh3A1 and Aldh1A1 showed increased cataract formation following UVB exposure, suggesting that Aldh1A1 may compensate for the loss of Aldh3A1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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