Thermo Fisher Scientific Septin 2 Polyclonal Antibody
Western blot과 IHC에 모두 사용 가능한 Rabbit Polyclonal 항체. Human, Mouse, Rat에 반응하며 SEPT2 단백질 특이적. 동결건조 형태로 제공되며, 4°C 단기 보관 또는 -20°C 장기 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human Septin 2 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage buffer | Whole serum |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity of this antibody: SEPT2.
Target Information
Septin 2 is a filament-forming cytoskeletal GTPase required for normal organization of the actin cytoskeleton. It plays a role in the formation of polarized epithelial cells by maintaining polyglutamylated microtubules, facilitating vesicle transport, and regulating MAP4 binding to tubulin.
It is essential for mitotic progression, forming a scaffold at the midplane of the mitotic spindle to maintain CENPE localization at kinetochores, ensuring chromosome congression.
During anaphase, Septin 2 is involved in chromosome segregation and spindle elongation, and also contributes to ciliogenesis and collective cell movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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