Thermo Fisher Scientific SHOX Polyclonal Antibody
SHOX 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간 시료에서 반응하며, Affinity chromatography로 정제되었습니다. PBS와 50% glycerol에 보관하며, -20°C에서 저장합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SHOX (Accession O15266), corresponding to amino acid residues Y35–F85 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853469 |
Product Specific Information
This antibody detects endogenous levels of total SHOX protein.
Target Information
Homeodomain proteins (HP) are transcriptional regulators that coordinate the expression of genes involved in development, differentiation, and cellular transformation. HPs are characterized by a conserved domain of 60 amino acid residues that recognize and bind to regulatory regions of target genes.
SHOX, a member of the bicoid subfamily of the paired homeobox family, controls fundamental aspects of growth and development and undergoes splicing resulting in two isoforms, SHOXA and SHOXB.
- SHOXA is expressed in skeletal muscle, placenta, pancreas, heart, and bone marrow fibroblast, and to a lesser extent in kidney and lung.
- SHOXB is highly expressed in osteogenic cells, but not expressed in brain, kidney, liver, or lung.
Defects in the SHOX gene cause Leri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia (LMD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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