
Thermo Fisher Scientific PAAF1 Monoclonal Antibody (OTI1F11)
PAAF1 단백질을 인식하는 Mouse monoclonal 항체로 Western blot 및 Immunocytochemistry에 적합. Human 및 Mouse 시료에 반응하며, 1 mg/mL 농도의 액상 형태로 제공. Affinity Chromatography로 정제되어 높은 특이성과 재현성을 보장. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:400–1:4,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F11 |
| Immunogen | Full length human recombinant protein of PAAF1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724921 |
Target Information
PAAF1 inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core.
In case of HIV-1 infection, it is recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of the 19S regulatory complex through dissociation of the proteasome 26S.
This process presumably enhances provirus transcription efficiency.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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