Thermo Fisher Scientific gamma crystallin S Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000
• Publications: [참고 문헌 없음]

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent
• Publications: [참고 문헌 없음]

Product Specifications

Target Information

Crystallins are divided into two classes: taxon-specific (enzyme) and ubiquitous. The ubiquitous crystallins are major proteins of the vertebrate eye lens, maintaining transparency and refractive index. Lens fiber cells lose their nuclei during development, so crystallins are synthesized once and retained throughout life, making them highly stable proteins.

Mammalian lens crystallins include alpha, beta, and gamma families. Beta and gamma crystallins form a superfamily, with alpha and beta further divided into acidic and basic groups. Each crystallin contains four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are highly symmetrical, monomeric proteins lacking connecting peptides and terminal extensions, and are differentially regulated after early development.

This gene encodes a protein initially considered beta-crystallin but is monomeric with greater sequence similarity to other gamma-crystallins. It represents the most significant gamma-crystallin in adult eye lens tissue. Aging or mutations in crystallin genes are associated with cataract formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.