Thermo Fisher Scientific ATF7 Polyclonal Antibody
ATF7 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 면역형광 분석에 적합합니다. 인간, 마우스, 랫트 반응성이며, 고순도 친화 크로마토그래피 정제 제품입니다. 액상 형태로 -20°C 보관, 연구용 전용입니다.
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Thermo Fisher Scientific ATF7 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ATF7 (Accession P17544), corresponding to amino acid residues P54–P104 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2854142 |
Product Specific Information
Antibody detects endogenous levels of total ATF7.
Target Information
ATF7 plays important roles in early cell signaling. It binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), found in many viral and cellular promoters.
Acts as an activator of the NF-ELAM1/delta-A site of the E-selectin promoter.
Has no intrinsic transcriptional activity but activates transcription when forming heterodimers with JUN or FOS.
Can also bind TRE promoter sequences when heterodimerized with JUN family members.
Isoform 4 (ATF-A0) functions as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.
Isoform 5 (ATF-4) acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities, potentially by sequestering the Thr-53 phosphorylating kinase in the cytoplasm and preventing activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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