Thermo Fisher Scientific Human RAP80 Synthetic Peptide

Thermo Fisher Scientific Human RAP80 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the carboxy terminus of human RAP80.
PEP-0530 can be used as a blocking peptide with polyclonal antibody PA5-20413.

Target Information

RAP80 was initially identified as a zinc-finger containing nuclear protein highly expressed in testis and interacting with the retinoid-related testis-associated receptor (RTR).
Later experiments revealed that RAP80 is recruited by Coiled-coil domain 98 (CCDC98) to the breast cancer-1 protein BRCA1, enabling BRCA1 foci formation in response to DNA damage from ionizing radiation.
Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair.
Cells depleted of RAP80 or CCDC98 show increased sensitivity to ionizing radiation, though less than BRCA1-depleted cells, suggesting RAP80 and CCDC98 mediate part of BRCA1’s DNA damage response.
At least four isoforms of RAP80 are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.