Thermo Fisher Scientific PLOD2 Monoclonal Antibody (OTI6D1)
PLOD2 단백질을 인식하는 마우스 모노클로날 항체로, Western blot 및 파라핀 포매 조직 면역조직화학에 적합합니다. 고순도 친화 크로마토그래피 정제 제품이며, PBS/BSA/glycerol 완충액에 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6D1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 359–640 of PLOD2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725046 |
Target Information
The protein encoded by this gene is a membrane-bound homodimeric enzyme localized to the cisternae of the rough endoplasmic reticulum. This enzyme, requiring iron and ascorbate as cofactors, catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resulting hydroxylysyl groups serve as attachment sites for carbohydrates in collagen, essential for intermolecular crosslink stability. Deficiencies in lysyl hydroxylase activity are linked to Ehlers-Danlos syndrome type VIB, and mutations in this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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