Thermo Fisher Scientific DKK1 Monoclonal Antibody (4B9B1H10)

Applications

ELISA

• Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

• This product is preservative-free.
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
• This antibody has specificity for Human Dkk1.

Target Information

DKK-1 is a member of the DKK protein family, which includes DKK-2, DKK-3, and DKK-4.
Originally identified as a Xenopus head-forming molecule, DKK-1 acts as an antagonist of Wnt signaling.
DKK-1 and DKK-4 regulate the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LRP5 and LRP6, co-receptors essential for Wnt signaling.
By inhibiting Wnt/β-catenin signaling, DKK-1 promotes anterior development.
Mice deficient in DKK-1 expression lack head formation and die during embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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