
Thermo Fisher Scientific DKK1 Monoclonal Antibody (4B9B1H10)
인간 DKK1 단백질을 인식하는 Mouse IgG2b 단클론 항체입니다. ELISA에 적합하며 보존제가 없는 액상 형태로 제공됩니다. 단백질 A로 정제되었으며, 4°C 단기 또는 -20°C 장기 보관이 가능합니다.
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Applications
ELISA
- Tested Dilution: 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B9B1H10 |
| Immunogen | Recombinant Human Dkk1 protein (Met2–His266) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C (avoid freeze/thaw cycles). |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2786078 |
Product Specific Information
- This product is preservative-free.
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
- This antibody has specificity for Human Dkk1.
Target Information
DKK-1 is a member of the DKK protein family, which includes DKK-2, DKK-3, and DKK-4.
Originally identified as a Xenopus head-forming molecule, DKK-1 acts as an antagonist of Wnt signaling.
DKK-1 and DKK-4 regulate the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LRP5 and LRP6, co-receptors essential for Wnt signaling.
By inhibiting Wnt/β-catenin signaling, DKK-1 promotes anterior development.
Mice deficient in DKK-1 expression lack head formation and die during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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