Thermo Fisher Scientific Lamin B2 Recombinant Rabbit Monoclonal Antibody (23GB2605)
Lamin B2 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단일클론 항체로, Western blot, ICC/IF, Flow cytometry에 적합. HEK293F 발현 시스템 사용, 고순도 친화 크로마토그래피 정제, 안정적인 PBS/glycerol 저장 buffer 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB2605 |
| Immunogen | A synthesized peptide derived from human Lamin B2 (570–620AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type and B-type lamins.
A-type lamins comprise lamin A, lamin C, and lamin Adel 10, which arise from the same gene via alternative splicing, while B-type lamins include lamin B1 and lamin B2, arising from distinct genes.
Mutations in A-type lamins are linked to rare dominant genetic disorders such as Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease, and Dunnigan-type familial partial lipodystrophy.
A-type lamins are expressed during cell differentiation and interact with chromatin, suggesting a role in regulation of differential gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-53498_Lamin_B2_Q03252-1_Rabbit.svg, MA5-53498_Lamin_B2_Q03252-1_Rabbit_PDP.jpeg)
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