Thermo Fisher Scientific VAMP A/B Polyclonal Antibody
VAMP A/B 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 동결건조 형태로 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunohistochemistry - Free Floating (IHC (Free)) | 1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 50–100 of human VAMPB conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in many species including human, rat, mouse, zebrafish, bovine, xenopus, and chicken.
- Specificity: VAMP A and B.
Target Information
VAPA/VAPB may play a role in vesicle trafficking. Present in the plasma membrane and intracellular vesicles. Interacts with VAMP1 and VAMP2.
Subunit: Homodimer and heterodimer with VAPA
Subcellular Location: Cell membrane; Single-pass type IV membrane protein. Intracytoplasmic membrane; Single-pass type IV membrane protein.
Tissue Specificity: Ubiquitous. Isoform 1 predominates.
Disease Associations:
- Defects in VAPB cause amyotrophic lateral sclerosis type 8 (ALS8), a neurodegenerative disorder affecting motor neurons and leading to fatal paralysis.
- Defects in VAPB also cause proximal adult autosomal dominant spinal muscular atrophy (Finkel type), a late-onset form with a benign course.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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