Thermo Fisher Scientific COMMD1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total COMMD1.

Target Information

Proposed scaffold protein implicated in diverse physiological processes, potentially linked to regulation of ubiquitination of specific cellular proteins.

• Modulates activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1.
• Promotes ubiquitination and proteasomal degradation of NF-κB subunit RELA, leading to down-regulation of NF-κB activity.
• Regulates membrane expression and ubiquitination of SLC12A2 and amiloride-sensitive sodium channel (ENaC) subunits.
• Promotes localization of SCNN1D to recycling endosomes and CFTR surface expression through regulation of ubiquitination.
• Involved in copper ion homeostasis and ATP7A trafficking between the trans-Golgi network and peripheral vesicles.
• Binds one copper ion per monomer and may facilitate biliary copper excretion in hepatocytes.
• Binds phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
• Regulates HIF1A-mediated transcription by competing with ARNT/Hif-1β, reducing DNA binding and transcriptional activation by HIF-1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.