Thermo Fisher Scientific LRWD1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human LRWD1. Recombinant protein control fragment (Product #RP-92783). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LRWD1,uniProtId:Q9UFC0-1,ncbiNodeId:9606,antigenRange:102-176,antigenLength:647,antigenImageFileName:PA5-54380_LRWD1_Q9UFC0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54380_LRWD1_Q9UFC0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643576

Product Specific Information

Immunogen sequence: PFLTVNDNLK VSFLLPTLRK VNGKDASSTY SQVENLNREL TSRVTAHWEK FMATLGPEEE AEKAQADFVK SAVRD

Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 77%.

Target Information

Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.