Thermo Fisher Scientific TRIM56 Polyclonal Antibody

Thermo Fisher Scientific TRIM56 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: DPKGSLLGDF LTAYHGLEKP RVTTMVDGRY LVVSLSNGTI HIFRVRSPDS
• Storage recommendations:
  • Short-term: 2–8°C up to 1 week
  • Long-term: -20°C in small aliquots to prevent freeze-thaw cycles
• Predicted homology:
  • Cow: 100%
  • Human: 100%
  • Mouse: 93%
  • Rat: 100%

Target Information

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to Lys-63-linked ubiquitination, promoting its homodimerization required for type I interferon (IFN-beta) production. Independently of its E3 ubiquitin ligase activity, acts as a positive regulator of TLR3 signaling. Potentiates extracellular dsRNA-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL, and CCL5/RANTES. Promotes antiviral state establishment by TLR3 ligand and TLR3-mediated chemokine induction following hepatitis C virus infection (PubMed:22948160). [UniProt]

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.