Thermo Fisher Scientific ATP6V1B1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 93% | Dog: 100% | Guinea Pig: 100% | Horse: 93% | Human: 100% | Mouse: 100% | Rabbit: 93% | Rat: 100% | Yeast: 86% | Zebrafish: 93%

Target Information

Vacuolar-type H⁺-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process to synthesize ATP.
The enzyme consists of:

• V1 domain: Responsible for ATP hydrolysis (subunits A–H)
• V0 domain: Responsible for proton translocation (subunits a, d, c, c′, c″)

V-ATPase likely operates through a rotary mechanism.
The V1 B subunit exists as two isoforms:

• B1 isoform: Functions in proton secretion in the inner ear, maintaining endolymph pH and auditory function.
• B2 isoform: Expressed in kidney and osteoclasts.
  Mutations in the human B1 isoform gene (chromosome 2cen–q13) cause distal renal tubular acidosis associated with sensorineural deafness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)