Thermo Fisher Scientific ALKBH7 Polyclonal Antibody
Thermo Fisher Scientific의 ALKBH7 Polyclonal Antibody는 인간 ALKBH7 단백질을 인식하는 토끼 다클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ALKBH7. Recombinant protein control fragment (Product # RP-102874) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2637869 |
Product Specific Information
Immunogen sequence:
SGPSVLSRLQ DAAVVRPGFL STAEEETLSR ELEPELRRRR YEYDHWDAAI HGFRETEKSR WSEASRAILQ RV
Highest antigen sequence identity to the following orthologs:
- Mouse: 78%
- Rat: 79%
Target Information
ALKBH7 (alkB, alkylation repair homolog 7), also known as SPATA11, is a 221 amino acid protein belonging to the alkB family.
ALKBH7 is one of many homologs of the Escherichia coli protein AlkB, which protects DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA.
The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent.
ALKBH7 is encoded by a gene located on human chromosome 19, which consists of over 63 million bases and houses approximately 1,400 genes, recognized for having the greatest gene density among human chromosomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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