Thermo Fisher Scientific LAMTOR1 Polyclonal Antibody
Rabbit polyclonal antibody against human LAMTOR1, suitable for WB and IP applications. Recognizes residues 111–161 of LAMTOR1. Predicted to react with mouse, rat, bovine, and orangutan. Supplied as liquid, 1 mg/mL, stored at 4°C.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | – |
| Immunoprecipitation (IP) | Assay-dependent | – |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 111 to 161 of human Ragulator complex protein LAMTOR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, and Orangutan
Target Information
The Ragulator complex is composed of three proteins—C11orf59, ROBLD3, and MAPKSP1—which target mTORC1 to lysosomal surfaces. This endosomal trafficking mechanism is exploited by certain viruses, including coronavirus, which shows increased replication when C11orf59 is disrupted.
C11orf59 is positively regulated by cholesterol depletion and negatively regulated by cholesterol loading, playing a role in LDL uptake and cholesterol homeostasis. Together with PPAR-alpha, it influences lipid and carbohydrate metabolism in diabetes. Most effects of C11orf59 are associated with mTORC1 kinase–mediated growth promotion, and dysregulation of this pathway can affect normal cellular metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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