Thermo Fisher Scientific Human CD180 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids near the carboxy terminus of human RP105.
PEP-0372 can be used as a blocking peptide with polyclonal antibody PA5-20250.

Target Information

CD180 (also known as RP105, Bgp95, LY64) is a type I membrane glycoprotein belonging to the Toll-like receptor (TLR) family. The cytoplasmic tail of CD180 is short and lacks the TIR domain found in other TLRs. Its expression depends on the coexpression of the helper molecule MD-1 and parallels that of TLR4 on antigen-presenting cells.

CD180 regulates the recognition of LPS and signaling in B cells by interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and an increase in cell size. Structurally, CD180 contains extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail, forming part of the RP105/MD-1 receptor complex.

Diseases associated with CD180 dysfunction include Kawasaki Disease in children and potential roles in rheumatic disease pathology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.