Thermo Fisher Scientific CLN3 Polyclonal Antibody
CLN3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며 인간 시료에 반응. 고순도 항원 친화 크로마토그래피 정제, PBS/glycerol 저장. Batten 병 관련 연구에 활용 가능.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 192–288 of CLN3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| RRID | AB_2553178 |
Product Specific Information
- Recommended positive controls: Jurkat, Raji, NCI-H929, NT2D1
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CLN3 is a highly glycosylated, hydrophobic, 438-amino acid protein with six transmembrane domains. The CLN3 protein localizes to the lysosomal membrane and plays a role in lysosomal function. It may act as a chaperone involved in the folding and unfolding of other proteins, such as subunit C of the ATP synthase complex.
Mutations in the CLN3 gene cause Batten disease, a recessively inherited neurodegenerative disorder of childhood characterized by lysosomal accumulation of hydrophobic material, mainly ATP synthase subunit C. Batten disease is the most common form of neuronal ceroid lipofuscinoses (NCLs). Symptoms include progressive loss of vision, seizures, and psychomotor disturbances.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-35868_CLN3_Q13286-1_Rabbit.svg)
(이미지: PA5-35868_CLN3_Q13286-1_Rabbit_PDP.jpeg)
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