Thermo Fisher Scientific p53 Monoclonal Antibody (PAb 1801)
인간 p53 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, IP, ChIP 등 다양한 연구용 응용 가능. 고순도 정제된 액상 형태로 제공되며, -20°C에서 안정적 보관. 암 연구 및 세포 스트레스 반응 연구에 적합.
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Thermo Fisher Scientific p53 Monoclonal Antibody (PAb 1801)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 11 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:500 | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
| ChIP assay (ChIP) | – | View 1 publication |
| Miscellaneous PubMed (Misc) | – | View 4 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PAb 1801 |
| Immunogen | Recombinant p53 peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533018 |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. Upon activation, p53 induces transcription of genes such as p21waf1, regulating G1 or G2/M arrest.
Structurally, p53 comprises:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerisation domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a vital role in preventing proliferation of damaged cells and acts as an anticancer agent. It is also implicated in aging, oxidative stress, and memory-related processes.
In normal cells, p53 levels are low, but in transformed or malignant cells, expression is elevated. Mutations in p53 disrupt DNA binding and tumor suppressor activity, contributing to cancer development. Alterations of the TP53 gene occur as somatic or germline mutations, such as in Li-Fraumeni syndrome.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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