Thermo Fisher Scientific p53 Monoclonal Antibody (PAb 1801)

Thermo Fisher Scientific p53 Monoclonal Antibody (PAb 1801)

Applications and Tested Dilutions

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. Upon activation, p53 induces transcription of genes such as p21waf1, regulating G1 or G2/M arrest.

Structurally, p53 comprises:

• N-terminal transactivation domain
• Central DNA-binding domain
• Oligomerisation domain
• C-terminal regulatory domain

Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a vital role in preventing proliferation of damaged cells and acts as an anticancer agent. It is also implicated in aging, oxidative stress, and memory-related processes.

In normal cells, p53 levels are low, but in transformed or malignant cells, expression is elevated. Mutations in p53 disrupt DNA binding and tumor suppressor activity, contributing to cancer development. Alterations of the TP53 gene occur as somatic or germline mutations, such as in Li-Fraumeni syndrome.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.