Thermo Fisher Scientific RhoH Polyclonal Antibody

Thermo Fisher Scientific RhoH Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunogen sequence:
  KWIGEIRSNL PCTPVLVVAT QTDQREMGPH RASCVNAMEG KKLAQDVRAK GYLECSALSN RGVQQVFECA VRTAVNQARR RNRRRLFSIN ECKI
• Highest antigen sequence identity to orthologs:
  Mouse – 94%, Rat – 94%

Target Information

The Rho subfamily of small GTP-binding proteins mediates many fundamental cellular functions. The commonly studied members (Rho, Rac, and CDC42) regulate actin reorganization and affect diverse cellular responses, including adhesion, cytokinesis, and motility.
RhoH, also known as TTF (Translocation Three Four), Rho-related GTP-binding protein, and ras homolog gene family member H, differs from most other small G proteins. While most small G proteins are expressed ubiquitously, RhoH is expressed only in hemopoietic cells and tissues.
Translocations and frequent RhoH mutations have been detected in primary lymphoma cells, and RhoH expression has been observed in activated neutrophils. RhoH is GTPase-deficient, remaining in a GTP-bound activated state without cycling.
RhoH may be involved in functional differentiation of T cells and cytoskeleton organization. The RhoH/TTF (ARHH) gene maps to chromosome 4p13 and encodes a 191-amino acid polypeptide.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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