Thermo Fisher Scientific FRMD2 Polyclonal Antibody
FRMD2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 어플리케이션에 사용 가능. 고순도 Protein A 정제 및 1 mg/mL 농도, -20°C 보관. 연구용 전용 제품.
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Thermo Fisher Scientific FRMD2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human FRMD2/FRMPD1 (amino acids 171–280) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, ezrin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula occludens-1) domain.
FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), which stabilizes the GDP-bound conformation of Gαi. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment.
Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased endogenous AGS3 in membrane fractions by ~50% and enhanced inhibition of forskolin-induced increases in cAMP.
Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gαi3, suggesting that FRMPD1 positions AGS3 in the membrane for interaction with Gαi.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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