Thermo Fisher Scientific ATP11A Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ATP11A. Recombinant protein control fragment (Product #RP-94972). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ATP11A,uniProtId:P98196-1,ncbiNodeId:9606,antigenRange:697-791,antigenLength:1134,antigenImageFileName:PA5-57324_ATP11A_P98196-1_Rabbit.svg,antigenImageFileNamePDP:PA5-57324_ATP11A_P98196-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638347

Product Specific Information

Immunogen sequence: TCYACKLFRR NTQLLELTTK RIEEQSLHDV LFELSKTVLR HSGSLTRDNL SGLSADMQDY GLIIDGAALS LIMKPREDGS SGNYRELFLE ICRSC

Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.

Target Information

ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.