Thermo Fisher Scientific HDAC8 Monoclonal Antibody (4C3)
Rabbit monoclonal antibody (clone 4C3) specific for human HDAC8 protein. Validated for WB, IHC-P, and ICC/IF applications. Supplied as unconjugated liquid form at 1 mg/mL. Suitable for chromatin remodeling and transcription regulation research.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C3 |
| Immunogen | Recombinant human HDAC8 protein, around N-terminal 150aa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is a critical component of transcriptional regulation, largely influenced by histone acetylation and deacetylation. Acetylation of lysine residues in histone tails increases DNA accessibility to transcription factors, while deacetylation is linked to transcriptional silencing.
Several mammalian proteins act as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase homologous to other HDACs but with distinct tissue distribution. HDAC8 is localized to the nucleus and plays a role in tissue development and cancer etiology.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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