Thermo Fisher Scientific MPP5 Polyclonal Antibody
MPP5 단백질을 표적하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체로, 인간 시료에 반응하며 WB, IHC, ICC, Flow 등 다양한 응용에 적합합니다. 액상 형태로 제공되며, 고순도 정제 및 안정적 저장 조건을 갖추어 연구용으로 최적화된 제품입니다.
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Thermo Fisher Scientific MPP5 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (NKASPPFPLISNAQ) corresponding to the N-terminus amino acids of MPP5 (aa 174–188) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10984108 |
Product Specific Information
- Predicted to react with canine and porcine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
MPP5 (Membrane Protein, Palmitoylated 5) plays a critical role in neurogenesis and hematopoiesis.
It is essential for establishing and maintaining cell polarity in epithelial cells and neurons.
MPP5 is part of the Par-3 complex, contributing to tight junction maintenance in epithelial cells.
Mutations in MPP5 are associated with severe neurologic impairments, including global developmental delay (GDD) and behavioral changes.
In animal models, MPP5 supports differentiation of multipotent progenitors and contributes to myeloid and lymphoid lineages.
Variants disrupt normal cellular function, leading to developmental and functional abnormalities.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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