Thermo Fisher Scientific PHF17 Polyclonal Antibody
PHF17 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 검증 완료. HeLa, HepG2 양성 대조군 권장. 인간, 생쥐, 랫트 등 다양한 종에서 예측 반응성. 연구용으로만 사용.
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- PA528504
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: [References available]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
- Publications: [References available]
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 298–536 of Human PHF17 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.77 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545980 |
Product Specific Information
- Recommended positive controls: HeLa, HepG2
- Predicted reactivity: Mouse (94%), Rat (96%), Rhesus Monkey (100%), Bovine (95%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Scaffold subunit of some HBO1 complexes, which have histone H4 acetyltransferase activity (PubMed:16387653, 19187766, 20129055, 24065767).
Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac, H4K12ac), regulating DNA replication initiation (PubMed:20129055, 24065767).
May promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158).
Promotes apoptosis and may act as a renal tumor suppressor (PubMed:16046545).
Negatively regulates canonical Wnt signaling; cooperates with NPHP4 in this function (PubMed:22654112).
[UniProt]
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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